Fasting and Gallstones

author avatar Dr. Eric Berg 03/01/2024

Fasting And Gallstones: Reducing Risks

Recent years have seen a surge in the popularity of fasting, with people citing its potential advantages for weight loss, metabolic regulation, and general well-being. However, there are concerns about the possible risk of developing gallstones during prolonged periods without food intake.

Learn about the connection between fasting and gallstone formation by examining cholesterol concentration and bile production changes during fasting. Examine how varying lengths of fasts can impact one's risk for developing gallstones.

Delve into the role that gallbladder function plays during these periods without eating and consider dietary recommendations for reducing the risk of gallstone formation while still enjoying the benefits of intermittent fasting.

16:8 fasting illustration

The Connection Between Fasting and Gallstones

As fasting has become more popular, many individuals engage in intermittent or extended periods of fasting for various health benefits.

However, there is a potential issue that fasting may lead to the development of gallstones.

This piece will examine the possible connection between fasting and gallstone formation and explore how cholesterol levels and bile production are impacted when abstaining from food.

Cholesterol Concentration During Fasting

When you fast, your body undergoes several changes to adapt to the lack of food intake.

One such change involves the regulation of cholesterol levels in your blood. Studies have shown that fasting can lead to increased concentrations of cholesterol, a primary cause of gallstone formation. 

Bile Production Changes With Different Fasting Durations

In addition to affecting blood lipid levels, prolonged periods without eating also impact bile production within our bodies.

Bile, a liver product stored in the gallbladder, facilitates digestion by breaking down fats from our diet for absorption into our bloodstream.

  • Short-term fasts: During short-term fasts (upwards of around 24 hours), studies suggest that bile production decreases, which could lead to a higher risk of gallstone formation due to increased cholesterol concentration in bile.

  • Long-term fasts: On the other hand, during extended periods without food intake (several days or more), it has been observed that bile production increases again. This may help reduce the risk of gallstones by diluting cholesterol concentrations within the bile and promoting its proper flow through our digestive system.

Bile Salts Can Support Bile Production

Gallstones are a common problem and can cause severe pain in the upper abdomen. They form when bile hardens into tiny stones that block the bile ducts.

One way to prevent gallstone formation is by supporting healthy bile production.

Bile salts are compounds produced by the liver that help break down fats in food. They also aid in absorbing fat-soluble vitamins such as A, D, E, and K.

When you eat fatty foods, your body releases bile from the gallbladder to help digest them.

Ox Bile for Gallstones Prevention

If you're struggling with gallstone formation or want to promote healthy fat digestion, ox bile supplements could be an excellent option.

Ox-bile contains essential enzymes and acids for properly digesting dietary fat while preventing cholesterol buildup, leading to stone formation within your biliary system.

In addition to taking ox-bile supplements regularly with meals containing high-fat content, there are other ways you can promote healthy bile production:

  • Eating plenty of fiber-rich vegetables will keep things moving through your digestive tract so that waste doesn't build up, which can cause inflammation and lead to further complications such as pancreatitis.

  • Drinking plenty of water daily helps flush out toxins from our bodies, including those found within our livers, where most metabolic processes occur.

Fasting Duration Impact on Gallstone Risk

Understanding the effects of fasting duration on gallstone risk is crucial for individuals who practice intermittent fasting or extended periods of fasting.

A study involving nine healthy women sheds light on how varying fasting lengths affect bile saturation index, indicating potential gallstone development.

The study measured the participants' bile saturation index at different intervals during their fasts. As the length of a fast increased, there were fluctuations in the bile saturation index.

At 10-hour and 15-hour fasts, researchers noted increased cholesterol concentration within the bile, potentially leading to gallstone formation if sustained over time. However, the study also found that when participants reached a 20-hour fast duration, their bile saturation index reverted to baseline levels seen before they began fasting.

This suggests that prolonged fasting may reduce one's risk of developing gallstones by preventing excessive cholesterol concentration within the bile.

Gallbladder illustration

Gallbladder Function During Fasting Periods

During periods of fasting, the gallbladder undergoes significant changes.

One such change is that the organ ceases to concentrate bile after a specific duration of fasting. This phenomenon can be attributed to several factors, including hormonal fluctuations and alterations in bile production rates.

When food is ingested, hormones such as CCK are secreted, telling the gallbladder to contract and expel bile into the small intestine for digestion. However, during extended periods of fasting, CCK secretion decreases due to a lack of food intake.

As a result, there's less stimulation for gallbladder contraction and subsequent emptying.

Dietary Considerations for Reducing Gallstone Risks While Fasting

When combining fasting with a ketogenic diet, it's essential to understand how your dietary choices may influence your likelihood of developing gallstones. 

Adjusting carb intake can help minimize this risk without compromising the health benefits of both practices.

Carb Intake Recommendations for Optimal Results

One key factor in reducing gallstone risks is limiting carbohydrate consumption.

Insulin, an essential metabolic hormone, is released in response to carbohydrates. A high-carb diet causes elevated levels of insulin, which is associated with an increased risk of gallstones.

Evidence suggests that insulin lowers gallbladder muscle contractions, which can contribute to improper bile flow and the formation of bile sludge, the leading cause of gallstone formation. A nutritious low-carb diet like Healthy Keto® keeps carb intake low and promotes liver health and bile flow, crucial for preventing gallstones. 

Traditional Diets vs. Healthy Keto 

The traditional Western diet tends to be high in unhealthy fats, refined sugars, and processed foods - all factors linked with an increased risk of developing gallstones.

In contrast, Healthy Keto focuses on healthy fats, moderate protein intake, and low carbohydrate consumption, which supports weight reduction, mental clarity augmentation, and energy enhancement.

Because the risk of gallstone formation is linked to carbs, excess weight, and insulin resistance, a ketogenic diet helps to manage several risk factors of gallbladder disease. 


Intermittent fasting has been linked to changes in cholesterol concentration and bile production, which may affect gallstone risk depending on the duration of the fast.

During fasting periods, the gallbladder ceases concentration and may undergo an emptying process to replace concentrated bile. Following a Healthy Keto diet and supplementing with bile salt supplements is an excellent strategy to mitigate the risk of gallstones while fasting.


1. Does Fasting Prevent Gallstones?

Significantly prolonged fasting (around 20 hours), can help prevent gallstones by promoting bile flow and reducing cholesterol concentration. 

2. Can Skipping Meals or Fasting Increase the Risk of Gallstones?

Skipping meals or irregular eating patterns might increase the risk of gallstone formation, leading to an imbalance in the bile production and emptying process. However, when done correctly, intermittent fasting can reduce this risk by maintaining proper bile flow and avoiding excessive cholesterol concentration.

3. How Do You Prevent Gallstones When Losing Weight?

To prevent gallstones during weight loss, follow these steps:

  1. Maintain a balanced diet rich in fiber and healthy fats.

  2. Avoid crash diets that lead to drastic calorie reduction.

  3. Incorporate regular physical activity into your routine.

  4. Lose weight more gradually at a rate of about 1-2 pounds per week.

4. How Can I Prevent Gallstones Naturally?

Natural ways to prevent gallstone formation include:

  1. Follow a nutritious low-carb diet like Healthy Keto. 

  2. Drink plenty of water to stay hydrated.

  3. Avoid or limit alcohol consumption.

  4. Exercise regularly to maintain a healthy weight.

  5. Avoid eating refined carbs, sugars, and processed foods. 

Healthy Keto Guide for Beginner

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