CoQ10 vs. Fish Oil: Health Benefits and Uses Compared

April 8, 2025

CoQ10 vs. fish oil–what are their health benefits and uses, and which is better?

While CoQ10 is a naturally occurring antioxidant, fish oil is a rich source of omega-3 fatty acids involved in cellular integrity and balanced immune system responses.

Discover how CoQ10 and fish oil help maintain cellular function and promote cardiovascular health, and learn if combining these two dietary supplements is safe.

What is CoQ10

Coenzyme Q10, also known as CoQ10, is a vitamin-like compound found in almost every cell in the human body that plays a vital role in energy production.

Although the body can produce CoQ10, levels steadily decline with age, and certain prescription medications, such as statin drugs, can deplete CoQ10.

Benefits of CoQ10

CoQ10 is an antioxidant that interacts with free radicals, which are unstable by-products of metabolism that can affect cellular components such as DNA, proteins, and mitochondria.

CoQ10 plays an important role in supporting cellular health and energy production. It also helps promote brain and heart function and supports overall cardiovascular well-being.

Although all cells require CoQ10, tissues with increased energy needs, such as the heart, brain, and muscles, contain some of the highest concentrations of this antioxidant nutrient.

“Because of its antioxidant properties, CoQ10 helps maintain cellular integrity,” says Dr. Berg. “This plays a key role in promoting healthy heart, muscle, and brain function.”

A study published in Frontiers in Physiology found that CoQ10 also supports energy-making processes in vital organs, promotes metabolic balance, and can help boost exercise performance.¹

Downsides

While CoQ10 is generally well tolerated and considered safe for most people, sensitive individuals can experience gastrointestinal issues when taking dietary supplements containing CoQ10.

In addition, CoQ10 can interact with blood-thinning drugs and certain medications used to lower blood pressure, and it’s crucial to discuss the use of CoQ10 supplements with a healthcare professional to minimize the risk of adverse effects.

Dosage

Evidence published in Molecular Nutrition and Food Research suggests that a daily CoQ10 intake of between 300 and 400 milligrams can help promote heart function and support brain health.²

Most CoQ10 supplements are available in the form of ubiquinone or ubiquinol. While ubiquinone has a longer shelf life, ubiquinol is significantly more bioavailable and up to eight times better absorbed than ubiquinone.

Watch the video below to learn how CoQ10 can support overall health and well-being.

What is fish oil

Fish oil is derived from the flesh of fatty fish species such as sardines, mackerels, salmon, and herring.

Fish oils are rich sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two essential omega-3 fatty acids with health-promoting properties.

Research consistently confirms the potential health advantages of omega-3 fatty acids, and fish oil has become one of the most popular dietary supplements.

Benefits of fish oil

Fish oil provides omega-3 fats that help support a healthy inflammatory response, promote heart health, and maintain normal blood pressure.

Adequate intake of omega-3 fatty acids has also been linked to overall cardiovascular, cognitive, and cellular health.

EPA and DHA are involved in maintaining the membrane fluidity of blood cells, which helps support healthy blood flow and promotes normal clotting processes, which contribute to normal cardiovascular functions.

Omega-3 fatty acids also can have neuronal benefits, and evidence published in Nature suggests that EPA may enhance the production of serotonin, a crucial neurotransmitter that regulates moods, sleep, and cognition.³

In addition, EPA and DHA have been found beneficial for maintaining a balanced gut environment while supporting circulatory health, lipid balance, and muscle function.

Downsides of fish oil

While taking fish oil is generally considered safe, it’s important to be aware of potential downsides.

Some individuals, especially those with a sensitive digestive system, can experience a fishy aftertaste or bad breath when taking fish oil supplements. Combining fish oils with food can help minimize these issues.

Fish oil supplements aren’t recommended for people taking blood-thinning medication and those with blood clotting disorders.

DHA and EPA are natural blood thinners and can augment the effects of anticoagulant drugs such as warfarin, thereby increasing the risk of excessive bleeding.

Dosage

Taking between 1 and 2 grams of fish oil daily has been found to promote cognitive functions and enhance immune system defenses.

Higher doses of up to four grams have been studied for their safety and are sometimes used to support healthy triglyceride levels and promote cardiovascular function.

CoQ10 vs. fish oil: which is better?

While CoQ10 plays a role in cellular energy production, fish oil supplies omega-3 fatty acids that help maintain overall wellness, including supporting cardiovascular and cognitive function.

Both supplements provide unique benefits, especially when included as part of a balanced diet.

Fish oil may be a helpful addition for those looking to support general well-being, including individuals who are focused on supporting heart and brain health.

CoQ10 supplements may be a beneficial option to help support energy production, enhance the body’s antioxidant defenses, and promote overall cellular health.

Research published in the American Journal of Cardiology suggests that CoQ10 supplementation may be advantageous for individuals taking statin drugs and older adults, as they may be more likely to have lower CoQ10 levels.⁴

Can you take CoQ10 and fish oil together?

Taking CoQ10 and fish oil together is not only safe but can maximize their health benefits.

Both CoQ10 and fish oils support different physiological functions, and combining their effects may contribute to overall cellular health, immune support, and cardiovascular function.

However, it’s important to discuss using fish oil and CoQ10 with a healthcare provider if you have preexisting health conditions or are taking prescription medication to minimize the risk of side effects.

Key takeaways

CoQ10 vs. fish oil–what are their health benefits, and which is better?

CoQ10 is an antioxidant that supports cellular health and energy production, while fish oil may benefit heart health, immune support, and cognitive functions.

Combining CoQ10 and fish oil may help enhance their potential benefits, contributing to overall well-being and supporting various crucial bodily functions.

FAQ

1. Which one is better: CoQ10 or fish oil?

Whether CoQ10 or fish oil is better depends on your health needs and wellness goals.
CoQ10 may support cellular energy production, while fish oil has properties that help support healthy blood pressure, contribute to heart health, and enhance immune system defenses.

2. Can I take fish oil and CoQ10 together?

Taking fish oil and CoQ10 together is generally considered safe, and combining these supplements may offer various health benefits.
CoQ10 helps support energy production and offers antioxidant support, while fish oil may contribute to vascular health, support blood pressure regulation, and promote brain health.

3. Is fish oil good for your heart?

Fish oil is known for its potential heart-health benefits, largely due to its high omega-3 fatty acid content, which may help support balanced blood lipid levels and contribute to circulatory and vascular health.

4. What is fish oil good for?

Fish oil has been associated with supporting heart health, enhancing mood regulation, promoting brain function, and boosting immune health.

5. What is CoQ10 good for?

CoQ10 is an antioxidant that supports cellular integrity and enhances energy production, helping maintain normal cellular function and overall performance.

6. Who should not take CoQ10?

Individuals with blood clotting disorders and those taking blood-thinning medications should avoid CoQ10 due to its blood-thinning properties that can increase the risk of excessive bleeding.

7. How much fish oil should you take each day?

General intake recommendations suggest between 1 and 2 grams of fish oil daily.
However, doses of up to four grams have been examined for safety and are occasionally used to help maintain healthy triglyceride levels and support cardiovascular function.