Magnesium Supplements: Forms and How to Choose

Magnesium Supplements: Forms and How to Choose

Magnesium supplements are among the most popular dietary supplements, available in different forms that offer unique properties, absorption rates, and effects on the body.

Let’s look at the different types of magnesium supplementation and learn how to choose the best product to support your specific health and wellness goals. 

What is magnesium, and what does it do? 

Magnesium is an essential mineral that plays a vital role in the human body. It’s involved in over 300 enzymatic reactions, helping the body function properly and supporting overall well-being.

Maintaining optimal magnesium levels is associated with a wide range of health benefits, as this mineral can help support healthy blood pressure control, heart health, and nerve function.

These effects are largely linked to magnesium’s role in regulating muscle contractions, including those of smooth muscles in the cardiovascular system. Magnesium helps muscle fibers relax after contraction and supports proper nerve signal transmission, which allows muscles and nerves to work efficiently together.

This may explain why many individuals seeking to support relaxation, stress relief, and sleep optimization incorporate magnesium into their wellness routine. 

Magnesium has also been linked to neurotransmitter regulation, further highlighting its potential role in supporting balanced moods and mental well-being. 

“A healthy magnesium status has been linked to bone health, as it helps activate vitamin D, which in turn regulates the intestinal absorption of calcium, a critical nutrient for bone matrix maintenance,” explains Dr. Berg. 

Research published in Advances in Nutrition highlights magnesium’s critical role in maintaining physiological balance and supporting overall health.

The authors summarize, “Processes in which magnesium is a cofactor include, but are not limited to, protein synthesis, cellular energy production and storage, reproduction, DNA and RNA synthesis, and stabilizing mitochondrial membranes.”

In addition, magnesium has been investigated for its role in promoting cellular insulin signaling, which is essential for maintaining healthy blood sugar levels, supporting effective weight management, and helping regulate the body’s hormonal balance.

Woman reading supplement labels 
Image credit: Doucefleur/shutterstock.com

What are the different forms of magnesium?

Magnesium in its pure elemental form is extremely reactive and is always bound to carrier compounds or salts to stabilize it. However, these different forms can influence how well magnesium is absorbed, tolerated, and utilized in the body. 

Because of their chemical composition, certain forms of magnesium aren’t very soluble, which means they’re poorly absorbed and can increase the risk of intestinal side effects.

Forms of magnesium not recommended for long-term supplementation include:

  • Magnesium sulfate
  • Magnesium carbonate 
  • Magnesium oxide 
  • Magnesium hydroxide

In contrast, several other types of magnesium supplements are highly bioavailable, offering a more effective way to support mineral balance and overall health. 

Here are seven types of magnesium and their potential health benefits.

1. Magnesium citrate

Magnesium citrate is well absorbed and highly bioavailable, making it a suitable option for supplementation. 

The combination of magnesium and citrate can help muscles relax and support proper nerve activity, while its high solubility may also promote digestive functions and regular bowel movements.

Woman sleeping
Image credit: Pixel-Shot/shutterstock.com

2. Magnesium glycinate 

Magnesium glycinate, also called magnesium bisglycinate, is a form of magnesium attached to the amino acid glycine.

It’s a highly absorbable form and gentle on the digestive system, reducing the likelihood of stomach upset and other side effects.

Research published in Cureus found that magnesium glycinate helps promote a calm and balanced nervous system and supports relaxation, which can contribute to overall stress management and restful sleep.

3. Magnesium L-threonate 

Magnesium threonate, or magnesium L-threonate, is a unique form of magnesium that has the potential to cross the blood-brain barrier.

Its ability to enter the central nervous system has been linked with neurotransmitter balance, thereby supporting nerve signalling, cognitive functions, and mood regulation.

4. Magnesium malate

Magnesium malate combines magnesium with malic acid, an organic acid that plays a crucial role in facilitating cellular energy production, especially in muscle cells. 

This form of magnesium is often included in supplements intended to support muscle performance and promote recovery after physical activity. 

Circulatory system illustrating 
Image credit: Shot4Sell/shutterstock.com

5. Magnesium taurate 

Magnesium taurate, which contains the amino acid taurine, is generally considered to be well-absorbed and has been investigated for its potential benefits for blood vessel and heart function.

Evidence published in Medical Hypotheses suggests that both magnesium and taurine help support vascular integrity, and combining these two nutrients may enhance their effectiveness in maintaining normal circulatory function and overall cardiovascular health.

6. Magnesium chloride

Magnesium chloride can be absorbed through the skin and is typically found in transdermal magnesium products formulated for topical application rather than ingestion. 

This form of magnesium is often preferred for its potential to provide targeted muscle support, making it ideal for active individuals or those seeking greater comfort and improved mobility.

7. Magnesium orotate  

Magnesium orotate is a form of magnesium bound to orotic acid, a compound that helps facilitate its entry into cells.

This combination allows magnesium to efficiently reach muscle cells, where it may support energy production and contribute to physical performance, endurance, and strength.

Magnesium blood test  
Image credit: Kitsawet Saethao/shutterstock.com

How much magnesium do you need?

The body doesn’t store significant amounts of magnesium, and regular dietary intake is crucial to maintain adequate levels. 

Magnesium requirements vary by age, sex, and life stage, and the National Institutes of Health (NIH) has established recommended dietary allowances (RDAs) to guide intake.

Here are the daily RDAs for magnesium based on age and gender:

  • Ages 4 to 8: 130 mg
  • Ages 9 to 13: 240 mg
  • Ages 14 to 18:
    • Males: 410 mg
    • Females: 360 mg
  • Ages 19 to 30:
    • Males: 400 mg
    • Females: 310 mg
  • Ages 31 and older
  • Males: 420 mg
    • Females: 320 mg

During pregnancy, magnesium requirements increase, and an additional intake of 40 mg per day is recommended to help meet the mother’s higher nutritional demands.

Man eating junk food
Image credit: KinoMasterskaya/shutterstock.com

Factors that can affect magnesium need

According to data published by the NIH, many people fall short of recommended magnesium intake, leaving a large portion of the population at risk of magnesium deficiency. 

Diets high in processed foods often lack essential minerals, and soil depletion has further reduced the magnesium content of many whole foods. This can make it more challenging to obtain enough magnesium from the diet alone.

In addition, alcohol consumption, low stomach acid, and poor digestive health can reduce intestinal magnesium absorption, further raising the risk of inadequate levels.

Factors such as chronic stress and intense physical activity can increase the body’s nutrient demands, potentially leading to magnesium depletion if intake isn’t sufficient to meet these higher needs.

Furthermore, evidence published in Diabetes indicates that elevated insulin levels trigger excess magnesium excretion in the urine.

This highlights that diets high in refined carbohydrates and added sugars, which raise insulin levels, may contribute to magnesium depletion and increase the need for consistent dietary intake.

Medications such as proton pump inhibitors (PPIs), diuretics, antibiotics, and certain antacids can also interfere with magnesium absorption and increase the risk of deficiency. 

Woman holding a Magnesium Supplements bottle   
Image credit: Asier Romero/shutterstock.com

How to choose a magnesium supplement 

While magnesium supplements are widely available, not all products offer the same quality, making careful selection critical to support your health goals while minimizing the risk of adverse effects. 

The bioavailability of different magnesium compounds varies, meaning some forms are better absorbed than others, which can affect how effectively they help maintain healthy magnesium levels.

Forms such as magnesium glycinate, citrate, malate, and L-threonate are highly bioavailable and generally considered gentle on the digestive system. In contrast, magnesium oxide, carbonate, and hydroxide are less easily absorbed and may cause digestive discomfort.

In addition to magnesium capsules or tablets, powdered magnesium formulations offer faster absorption and greater dosage flexibility, making them an excellent choice for those seeking convenient, customizable supplementation.

It’s also important to choose products from reputable brands that undergo third-party testing to ensure quality, purity, and effectiveness.

Caution concept 
Image credit: SuPatMaN/shutterstock.com

Who should be cautious with magnesium supplementation? 

Magnesium supplementation is generally considered safe for healthy adults if taken as advised.

However, those with certain underlying health issues, such as impaired kidney function, specific heart rhythm disorders, or low blood pressure, should avoid magnesium supplements, as they may worsen these conditions or cause complications. 

Because certain medications, including those for heart disease, as well as diuretics, bisphosphonates, and antibiotics, can interact with magnesium, it’s important to speak to your doctor or pharmacist before incorporating supplements into your daily routine.

In addition, individuals with sensitive digestive systems may be more prone to gastrointestinal side effects and can often reduce discomfort by taking supplements with foods and splitting their daily magnesium intake into two doses.

Because many factors can affect magnesium requirements, absorption, and metabolism, it’s important to consult a healthcare professional for personalized guidance on the most effective magnesium form and dosage to support your specific health and wellness goals.

FAQ

1. What is the best form of magnesium supplement?

While magnesium citrate is often chosen for its support of muscle function and digestive comfort, magnesium glycinate is valued for promoting relaxation, reducing stress, and supporting restful sleep.

2. What is the RDA for magnesium?

The Recommended Dietary Allowance (RDA) for magnesium varies by age and sex, ranging from 130 mg per day for young children to 420 mg per day for adult men and 320 mg per day for adult women.

3. Should magnesium be taken with food?

Yes, it’s generally advised to take magnesium with foods to reduce the risk of gastrointestinal upset. However, magnesium glycinate and citrate are gentle forms of magnesium and may be tolerated without food. 

4. Is it good to take magnesium every day?

Supporting balanced magnesium levels daily can help maintain a healthy cardiovascular system, promote proper muscle function, and support overall nerve activity and metabolic processes.

In addition, magnesium glycinate can promote relaxation and help relieve stress, thereby supporting sleep quality, mood regulation, and overall health and well-being. 

Sources

  1. https://www.sciencedirect.com/science/article/pii/S2161831322011280 
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC11136869/ 
  3. https://www.sciencedirect.com/science/article/abs/pii/S0306987796900079 
  4. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#h3 
  5. https://pubmed.ncbi.nlm.nih.gov/26696633/ 

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