Health Benefits of Nattokinase

Nattokinase supplementation has recently gained attention for its potential to promote normal blood circulation and arterial health.

Let’s explore how nattokinase benefits can offer a natural approach to support cardiovascular wellness.

What is nattokinase?

Nattokinase is an enzyme naturally present in natto, a traditional Japanese dish that has been a staple health food in Japan for over 2000 years. 

Natto is made by fermenting soybeans with the bacterial species Bacillus subtilis. This fermentation process gives natto its distinctive sticky texture and umami flavor while also contributing to its health benefits.  

According to research published in Chinese Herbal Medicines, nattokinase has an impressive ability to help maintain normal blood viscosity and is believed to be “the most important active substance of natto.”¹

Watch the video below to learn more about the health benefits of nattokinase.

Health benefits of nattokinase

Nattokinase has been used holistically for several decades, but only in recent years have its potential health benefits been subjected to rigorous scientific testing.

Since then, nattokinase intake has been linked to several significant health advantages.

Here are four health benefits of nattokinase.

1. Promotes healthy blood flow

Also known as subtilisin NAT, nattokinase is primarily recognized for its ability to break down fibrin, the protein mesh that enables blood cell aggregation.

A study published in the Biological and Pharmaceutical Bulletin investigated nattokinase in an animal model and found it supported arterial blood flow and significantly outperformed other anti-clotting enzymes, including plasmin and elastase.²

Moreover, research published in the International Journal of Molecular Sciences noted that nattokinase has effects comparable to those of certain blood-thinners without adverse effects.³

This indicates that nattokinase may offer an alternative option to support the body’s ability to regulate optimal blood cell aggregation and enhance overall circulatory health.

2. Supports healthy cholesterol levels

Nattokinase has been studied for its influence on lipid metabolism, a critical factor in maintaining heart health.

A study published in Biomarker Insights found that 6500 fibrinolytic units (FU) of nattokinase over six months helped promote balanced cholesterol levels.⁴

Nattokinase was associated with favorable changes in lipid profiles, highlighting its potential as a natural option for supporting a healthy cardiovascular system.

3. Promotes healthy blood pressure 

Nattokinase may help maintain healthy blood flow by promoting normal red blood cell aggregation, which plays a vital role in blood pressure regulation. 

A study published in Integrated Blood Pressure Control found that nattokinase intake was associated with healthy systolic and diastolic blood pressure levels.⁵

This suggests nattokinase may be a valuable natural option for supporting healthy blood flow, which is crucial for cardiovascular health and overall well-being.

4. Supports cardiovascular health

A study published in Life Sciences examined how dietary supplementation with nattokinase affected the inner lining of blood vessels in rats.⁶ 

Researchers observed that nattokinase appeared to support the structure and flexibility of the arteries, which are critical factors for maintaining cardiovascular health.

Sources and dosage 

Nattokinase supplements are derived from soybean fermentation and are widely available in health stores and specialized online retailers.  

Dr. Berg explains, “Most soy crops are contaminated with toxic pesticides and insecticides and are some of the most genetically modified crops in the world.”

When choosing soy-derived products, opting for high-quality, certified organic, and non-GMO products is essential to minimize exposure to potentially harmful substances.

Recommended dosages of nattokinase vary but often range from 50 to 200 milligrams daily, which should provide around 2000 FU, a measure of the enzymatic activity of nattokinase.

However, a recent study published in Frontiers in Cardiovascular Medicine demonstrated that a significantly higher dose of oral nattokinase at 10,800 FU per day not only appears to be safe but may also be more effective in supporting markers of cardiovascular wellness.⁷

However, further research is needed to establish optimal nattokinase dosages, which may vary depending on individual health conditions.

Consult a healthcare professional before starting any new supplement regimen, including nattokinase, to ensure safety and appropriate dosage for your specific needs.

Downsides of nattokinase

While nattokinase is generally considered safe, there are some potential drawbacks and precautions to consider.

Because of its potential blood-thinning properties, individuals with cardiovascular diseases should consult a healthcare provider before taking nattokinase. Combining nattokinase with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Additionally, nattokinase is thought to influence blood flow by affecting blood thickness and the way red blood cells clump together. Because of this, individuals with certain underlying health considerations or who are taking specific medications should consult a healthcare professional before use.

Since nattokinase is derived from soybeans, individuals with soy allergies may experience allergic reactions when taking nattokinase supplements. If you have a soy allergy, it’s best to avoid nattokinase or consult a medical professional for guidance.

FAQ

Sources

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC10394349/ ?
2. https://www.jstage.jst.go.jp/article/bpb1993/ ?
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC5372539/ ?
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC6043915/ ?
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC5066864/ ?
6. https://www.sciencedirect.com/science/article/abs/pii/ ?
7. https://www.frontiersin.org/journals/cardiovascular-medicine/ ?