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author avatar Dr. Eric Berg 03/15/2024

CoQ10 and Statins: Impact on Cholesterol Levels

Understanding the complex relationship between CoQ10 and statins is vital for those aiming to balance heart health with overall wellness. This intricate interplay has significant implications, especially regarding managing cholesterol levels.

Discover how statin medications control cholesterol levels, the role of liver cells in producing it, and its importance for body functions, including when there's a deficiency in bile salts.

While these medications can be helpful, they may have unwanted consequences. We will unpack common issues associated with statin usage, focusing on myopathy – a significant concern linked with these medicines.

Learn about how taking CoQ10 supplements can help mitigate symptoms of myopathy caused by lowered coenzyme Q10 (CoQ10) levels due to statin use.

Understanding Statins and Cholesterol

The superheroes of cholesterol control. They swoop in, block that pesky enzyme called HMG-CoA reductase, and save the day by reducing your cholesterol levels. Take that, heart diseases and stroke.

The function of statins in controlling cholesterol levels

Statins work their magic by blocking HMG-CoA reductase, the mastermind behind cholesterol production in your liver. With this enzyme out of the picture, your liver produces less cholesterol, keeping your levels in check.

But wait, not all cholesterol is evil. Our bodies need cholesterol for essential tasks like building healthy cells and producing hormones. We should be wary of LDL cholesterol while celebrating the beneficial HDL.

Role of liver cells in producing cholesterol

Guess what? Your liver cells are the real MVPs when it comes to cholesterol production. They're responsible for about 75% - 80% of those pesky blood lipids, even if you eat a healthy diet. Talk about an inside job.

These liver cells are multitaskers. They create bile salts for digestion, synthesize fatty acids, and break down fats. It's like a lipogenesis party in there.

But wait, there's more. Circulating LDLs, the notorious "bad" cholesterols, also contribute to your body fat levels. They love forming arterial plaque and causing trouble. Watch out for those sneaky little troublemakers.

Cholesterol written on Post-it note

Importance of Cholesterol for Body Functions

Cholesterol gets a bad rap, but it's essential for our body's functions. Cholesterol, a waxy substance in every body cell, is critical for hormone production, vitamin D synthesis, and bile salt formation.

Vital roles played by Cholesterol in our bodies

The liver produces most of your body's cholesterol, which is used for:

  • Hormone Production: It helps make essential hormones like cortisol, estrogen, and testosterone.

  • Vitamin D Synthesis: Cholesterol in your skin converts to vitamin D when exposed to sunlight.

  • Bile Salt Formation: Cholesterol transforms into bile salts, which are needed for digesting fats and absorbing fat-soluble vitamins.

Health implications linked to insufficient bile salts

If you don't have enough bile salts, you may have trouble digesting fats and absorbing essential nutrients. Low levels can also lead to gallstones or pancreatitis. So, maintaining optimal cholesterol levels is crucial for overall well-being, especially on high-fat diets like the ketogenic diet.

While statins help manage high LDL cholesterol levels, they should be used cautiously due to potential side effects. Always consult a healthcare provider before starting or stopping any medication regimen.

Unpacking Statin Side Effects

Be mindful of the potential repercussions of taking statins to keep your cholesterol in check. These drugs lower LDL ("bad") cholesterol but have a downside.

Common side effects of statins

The most common side effects of statins include muscle pain, digestive problems, mental fuzziness, rash, and flushing. These usually subside as your body adjusts. Be wary of possible liver harm and higher glucose levels that may result in type 2 diabetes.

Muscle pain is a significant complaint among users. It can range from mild soreness to debilitating pain, making daily activities difficult.

Myopathy - A significant side effect

Myopathy is often associated with high statin doses but can occur at any level. It disrupts muscle protein production, leading to inflammation and breakdown.

Doctors look for elevated creatine kinase (CK) levels when diagnosing myopathy. Not all patients with muscle issues will show raised CK values.

In extreme cases with high CK levels and severe symptoms, rhabdomyolysis may develop. This requires immediate medical attention.

CoQ10 Depletion Due To Statins And Its Implications

Great for cholesterol, but not so great for CoQ10. These drugs can zap your body's energy enzyme, leaving you feeling less than stellar.

The link between Statins and depletion of CoQ10

Statins not only block cholesterol production, but they also mess with mevalonate, a key player in CoQ10 synthesis. So, when you take statins, your CoQ10 levels take a nosedive. Bummer, right?

CoQ10 is like a little energy spark plug, especially for organs that need a power boost. But when it's in short supply, your cells might struggle to keep the lights on. Talk about a power outage.

Potential health issues arising from deficiency of CoQ10

Low on CoQ10? Brace yourself for some muscle mayhem. Weakness, pain, and even cognitive issues can creep up on you. And if that's not enough, heart failure risks might even skyrocket. Yikes.

Mitigating Symptoms of Myopathy with CoQ10 Intake

Statins, while effective in controlling cholesterol levels, can lead to specific adverse effects such as myopathy.

Statin use can lead to Coenzyme Q10 (CoQ10) depletion, which in turn causes myopathy symptoms such as muscle pain, tenderness, or weakness. However, there are ways to mitigate these side effects.

Stethoscope on wood with Signs and Symptoms

Efficacy of Using CoQ10 in Alleviating Myopathic Symptoms

Research suggests that supplementing your diet with CoQ10 could potentially help alleviate some symptoms tied directly to myopathy. CoQ10 is vital in cell energy production and is particularly important for maintaining healthy muscle function.

Notably, our bodies generate this enzyme, but its production can decrease with age or when taking certain drugs such as statins.

Taking CoQ10 supplements alongside your prescribed medication might be beneficial if you're experiencing any form of muscle discomfort due to statin usage.

A study in the American Journal of Cardiology found that taking 100mg of CoQ10 daily significantly improved muscular symptoms compared to those who didn't.

  • Dosage: The typical dosage ranges from 90 to 200 mg per day divided into two doses; however, you must consult your healthcare provider before starting any new supplementation regimen.

  • Safety: Generally speaking, taking up to 1200mg/day has been deemed safe according to studies, but again, it's best practice to consult with your doctor first, especially if you're already on other medications.

  • Potential Side Effects: While generally well-tolerated, possible side effects may include mild insomnia, rashes, or nausea, which usually subside after discontinuing use.

In addition to alleviating myopathic symptoms explicitly related to statin usage, supplementing with CoQ10 also comes packed with other health benefits.

For instance, it acts as an antioxidant, protecting us against oxidative stress and cellular damage, supports heart health, and even helps maintain optimal skin health.

To sum up, if you're currently on statins and experiencing uncomfortable side effects like muscle wasting or weakness, consider discussing adding a high-quality

Coenzyme Q10 supplement and your current treatment plan during your next visit to the doctor's office.


Understanding the CoQ10 and statins relationship is crucial for those taking cholesterol-lowering meds - it's like knowing the secret handshake to a healthy heart.

Statins are like the bouncers at the liver nightclub, making sure excessive cholesterol doesn't get in - but let's not forget that cholesterol has its own VIP perks, like hormone production and cell membrane formation.

Unfortunately, statins can have some not-so-fun side effects, like myopathy - a real party pooper that causes muscle weakness and pain by depleting CoQ10 levels.

But fear not; supplementing with CoQ10 can be the ultimate wingman, supporting your health while on statins.

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