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Do Gallstones Come From High Cholesterol

author avatar Dr. Eric Berg 03/07/2024

Understanding the role of cholesterol in gallstone formation is crucial for effective prevention strategies.

Discover the relationship between cholesterol and gallstones and how bile salts can help to lower the risk of stone formation. Learn about several causes of decreased bile production, such as high estrogen levels, elevated cortisol levels, insulin resistance, and liver damage.

The Link Between Gallstones and Cholesterol

Gallstones are a common health issue that affects millions of people worldwide. They form in the gallbladder, a small organ under the liver responsible for storing bile.

Gallstones consist mainly of cholesterol, about 80% of their composition.

Role of Bile in Gallstone Prevention

Bile plays an essential role in breaking dietary fats into smaller particles and helps dissolve excess cholesterol in bile fluid, thereby preventing its crystallization, which causes gallstone formation.

To prevent or manage gallstone issues effectively, it's essential to maintain balanced cholesterol levels and support adequate bile production and bile flow.

Incorporating plenty of high-fat foods stimulates bile release, while low-fat diets can lead to insufficient gallbladder contraction, which, over time, can cause supersaturated bile and, subsequently, gallstones.

A ketogenic diet has been found to inhibit gallstone formation by stimulating bile release and promoting balanced cholesterol levels.

Causes of Decreased Bile Production

Bile production can be decreased by various factors, resulting in an increased risk of gallstone formation.

Elevated estrogen

High estrogen levels can cause a reduction in bile flow by impairing the liver's ability to produce it effectively, which is especially relevant for women taking oral contraceptives or undergoing hormone replacement therapy.

High cortisol

Elevated cortisol levels have been linked to decreased bile production, and managing stress through relaxing activities such as deep breathing, walking in nature, hiking, or gardening may help maintain healthy cortisol concentrations and support proper digestion.

Insulin resistance

Prediabetes or diabetes and elevated insulin concentrations can negatively affect your body's ability to produce sufficient amounts of bile necessary for fat breakdown.

Adopting a nutritious low-carb diet like Healthy Keto® in combination with intermittent fasting helps improve insulin sensitivity and is essential for maintaining optimal bile production.

Liver damage

Conditions like fatty liver disease can impair the liver's ability to function correctly, leading to decreased bile synthesis.

Addressing underlying causes of liver damage through dietary changes, weight loss, or medical intervention may help restore normal bile levels.

Vitamin K deficiency, Doctor writing on transparent screen

Nutrient deficiencies

  • Folic Acid: A deficiency in this B vitamin has been associated with reduced bile secretion, so consuming foods rich in folic acids, such as leafy greens, sunflower seeds, eggs, seafood, and avocado, can help support proper digestion.

  • Magnesium: Low magnesium concentrations have also been linked to gallstone formation due to its impact on cholesterol metabolism, so incorporating magnesium-rich foods like nuts, seeds, and dark chocolate into your diet may contribute positively towards preventing gallstones.

High-Fat Diets May Reduce Gallstone Risk

Contrary to popular belief, consuming dietary fats can help prevent gallstones by stimulating the release of concentrated bile.

Consuming dietary fats triggers the liver to produce and release more concentrated bile, which breaks down dietary fats and prevents cholesterol from forming stones.

Low-Fat Diets Can Lead to Stone Formation

Following a low-fat diet can cause insufficient bile usage, leading to excess cholesterol crystallizing into stones.

Studies show that women on a low-fat diet have twice the risk of developing gallstones than those who consume more fats.

The Benefits of Keto For Gallbladder Health

A high-fat, low-carb keto diet stimulates your body to burn fat for energy and triggers bile production to digest and absorb dietary fats efficiently.

Fat Intake and Bile Flow:

  1. Promotes regular bile flow: Healthy fats stimulate regular contractions within the gallbladder, preventing stagnation and buildup that can lead to stone formations.

  2. Dilutes cholesterol concentration: Breaking down cholesterol particles into smaller ones makes them easier to absorb, preventing excesses from forming stones and ensuring optimal cardiovascular health.

  3. Maintains proper hormone balance: The keto diet may help regulate hormones such as insulin and cortisol that play significant roles in bile production, reducing the risk of gallstone formation.

Incorporating intermittent fasting alongside keto may benefit bile production and overall digestive health.

Fasting periods give your body time to rest and recover from digestion processes, allowing it to focus on producing more concentrated bile when needed during eating windows.

Purified Bile Salts: Your Gallstone Prevention Strategy

Purified bile salts promote healthy digestion and may lower your risk of gallstone formation. Studies show that purified bile salt supplements with a high-fat diet can improve overall health and reduce the risk of developing gallstones.

Look for high-quality products that blend different bile salts like TUDCA for maximum benefits, including:

  • Helps emulsify fats for better absorption.

  • Increases cholesterol solubility to prevent stone formation.

  • Stimulates bile production for proper digestion.

  • Supports liver function for overall health.


A low-fat diet may not be effective, as it can cause insufficient bile usage and lead to stone formation. On the other hand, a high-fat ketogenic diet can increase bile synthesis and prevent gallstone formation by stimulating the release of more concentrated bile.

Healthy bile production is critical to preventing gallstones, but factors like high estrogen levels, cortisol secretion, insulin resistance, or liver damage can decrease bile production and lead to stone formation. If you are experiencing low bile production, please speak with your physician about adding bile salt supplements to your diet.


1. How to Prevent Cholesterol Gallstones?

To prevent cholesterol gallstones, maintain a healthy weight, follow a nutritious high-fat diet like Healthy Keto®, avoid rapid weight loss, exercise regularly, and consider taking purified bile salts to promote better digestion.

2. How to Reduce Cholesterol and Gallstones?

Reducing cholesterol concentrations in bile alone may not directly reduce gallstone risk. However, a healthier lifestyle can help balance cholesterol levels and promote optimal bile production for effective gallstone prevention.

3. What is The Relationship between High Cholesterol and Gallstones?

Excess dietary cholesterol can produce supersaturated bile with higher cholesterol concentrations, forming crystals and eventually developing into gallstones.

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