The First Complication in Diabetes or Prediabetes

author avatar Dr. Eric Berg 04/30/2024

Hey there, I want to tell you something that might shock you. Working closely with those affected by diabetes, I've observed firsthand its destructive path through their well-being. But here's the kicker - it's not just about high blood sugar.

A shady process known as glycation is behind a whole lot of health issues. And the real shocker? The very medications meant to help can actually make it worse.

I know, it's a lot to take in. But stick with me, because understanding this is crucial for anyone dealing with diabetes. We'll explore how glycation works, the sneaky ways it contributes to complications, and most importantly - what you can do to fight back.

Understanding Diabetes Mellitus and Its Initial Complications

Diabetes mellitus is a chronic condition that affects millions of people worldwide. It's characterized by high blood sugar levels, which can lead to a range of health complications if left unchecked.

But before we dive into the nitty-gritty of diabetes complications, let's first understand what happens in the body during the early stages of this disease.

When you have diabetes, your body either doesn't produce enough insulin or can't use it effectively. Insulin is a hormone that helps regulate blood sugar levels by allowing cells to absorb glucose from the bloodstream.

Without enough insulin or with insulin resistance, glucose builds up in the blood, leading to high blood sugar levels.

The Role of Insulin in Early Diabetes

In the early stages of diabetes, your body may actually produce more insulin than usual to compensate for rising blood sugar levels.

This is known as hyperinsulinemia. While this increased insulin production can initially help manage blood sugar, it's not a sustainable solution.

Over time, the pancreas (the organ responsible for producing insulin) becomes overworked and may start to fail. This can lead to a decrease in insulin production and, eventually, full-blown diabetes mellitus.

Transition from Normalcy to Pre-Diabetes

Before developing diabetes, many people go through a stage called pre-diabetes. This is when blood sugar levels are higher than normal but not high enough to be diagnosed as diabetes. It's a gradual process that can take years to develop.

During this transition period, the body's cells become increasingly insulin-resistant. As a result, more insulin is needed to help glucose enter the cells.

This increased demand for insulin puts extra stress on the pancreas, which can eventually lead to the development of type 2 diabetes.

It's important to note that the first complication in diabetes is often high insulin levels, which initially work to lower blood sugar.

However, as the disease progresses and insulin resistance increases, blood sugar levels start to rise, signifying the onset of pre-diabetes. If left unchecked, this can lead to significantly elevated blood sugar levels and, ultimately, full-blown diabetes.

The Glycation Process and Its Impact on Diabetic Patients

Now that we've covered the basics of how diabetes develops, let's discuss one of the key processes that contributes to diabetic complications: glycation.

Glycation occurs when sugar molecules combine with proteins or fats in the body, forming what are known as advanced glycation end products (AGEs).

AGEs can accumulate in various tissues and organs, leading to inflammation, oxidative stress, and cellular damage. This process is accelerated in people with diabetes due to the persistently high blood sugar levels associated with the condition.

Sugar alternative

Dietary Influences on Glycation

Did you know that the foods you eat can significantly impact the glycation process? Consuming foods high in sugar and fat or sugar and protein that have been heated (think grilled meats, fried foods, and baked goods) can lead to the formation of AGEs in the body.

Fructose, a type of sugar found in many processed foods and beverages, is particularly problematic regarding glycation. In fact, research has shown that fructose can increase glycation by up to 10 times more than other sugars like glucose.

Medication and Excess Sugar Accumulation

While medications for diabetes, such as insulin and oral hypoglycemic agents, are designed to lower blood sugar levels, they don't necessarily address the issue of excess sugar accumulation in the body.

As these medications work to reduce blood sugar, the excess sugar has to go somewhere.

Unfortunately, this excess sugar can contribute to the glycation process, leading to the formation of AGEs and the development of diabetic complications.

It's a bit like sweeping dirt under the rug - just because you can't see it doesn't mean it's not there, causing damage over time.

To make matters worse, the accumulation of AGEs can further impair insulin sensitivity and pancreatic function, creating a vicious cycle that exacerbates the progression of diabetes and its complications.

The Consequences of Excess Sugar Accumulation in Diabetic Patients

So, what happens when excess sugar continues to accumulate in the body due to a combination of dietary factors and medication use? The consequences can be severe and far-reaching, affecting multiple organ systems and leading to various health problems.

Visualizing Sugar Accumulation

Let's use an analogy to better understand the impact of excess sugar accumulation. Imagine your body as a house, with each room representing a different organ or tissue. Now, picture sugar as fine dust that settles on every surface, gradually building up over time.

At first, the dust may seem harmless - a little here, a little there. But as it accumulates, it starts to interfere with the normal functioning of your house.

The dust clogs the air filters (your blood vessels), strains the electrical system (your nerves), and even compromises the structural integrity of the building (your organs).

Three different faces of a woman

Health Problems Stemming from Sugar Accumulation

The accumulation of excess sugar in the body can lead to a wide range of health problems, many of which are commonly associated with diabetes. These include:

  • Diabetic retinopathy, a condition that affects the blood vessels in the retina and can lead to vision loss

  • Diabetic nephropathy, which involves damage to the kidneys and can result in kidney failure

  • Diabetic neuropathy, a type of nerve damage that can cause pain, numbness, and weakness

  • Cardiovascular disease, including heart attack and stroke

  • Slow wound healing and increased risk of infection

These complications arise due to the combined effects of glycation, oxidative stress, and inflammation caused by excess sugar accumulation. The longer blood sugar levels remain uncontrolled, the greater the risk of developing these serious health problems.

As someone who has witnessed the devastating impact of diabetic complications firsthand, I cannot stress enough the importance of taking steps to manage blood sugar levels and reduce the accumulation of excess sugar in the body.

By making informed dietary choices, working closely with healthcare providers, and staying vigilant about monitoring blood sugar, those with diabetes can significantly reduce their risk of developing these life-altering complications.

Glycation Glimpse

Delve into the intricate relationship between diabetes complications, glycation, and the perceived health impacts of sugar alcohols.

Diabetes brings with it a host of potential complications, including cardiovascular disease, neuropathy, and retinopathy, largely attributed to elevated blood sugar levels and subsequent glycation processes.

Amidst this discussion, questions arise: is sugar alcohol bad for you? While sugar alcohols are often marketed as a healthier alternative to traditional sugars due to their lower impact on blood glucose levels, concerns linger regarding their potential effects on health.

By dissecting the science behind glycation and scrutinizing the evidence surrounding sugar alcohols, this exploration aims to clarify their role in diabetes management and overall health outcomes.


Complications of diabetes and glycation - it's a bitter pill to swallow, isn't it? We've seen how excess sugar, both from diet and medication, can accumulate in the body and wreak havoc. This process creeps up slowly but can really mess with your health over time.

But here's the thing - knowledge is power. Once you've cracked the code on how glycation affects diabetic troubles, consider yourself way ahead.

Dialing in on the perfect diet. Navigating through medication options; Crafting a custom-fit game plan - it all adds up when managing your diabetes effectively.

It's not always easy, but it's worth it. Trust me, your body will be all kinds of happy when you stay ahead of diabetes and those sneaky glycation issues. So keep learning, keep fighting, and most importantly - don't lose hope. You've got this.

Healthy Keto Guide for Beginner

FREE Keto Diet Plan